• Deborah Verga

How Peptides Help Mature Skin


It's great to know how peptides help mature skin. But, what exactly are peptides, and what is actually considered mature skin?


What are Peptides?

Peptides are communicators.


They're small chemical compounds of short chains of amino acids that make up certain proteins needed by the skin.


In a nutshell, peptides tell your skin cells to produce more collagen, elastin, and keratin.


Collagen is one of the major building blocks of your skin.


The cool thing... we can apply these peptides topically and they will tell our skin cells to make more collagen!


When you apply peptides topically you're tricking your skin into thinking it's injured, thereby signaling your skin cells to make more collagen, elastin, and keratin. Pretty cool, right?!


These proteins are responsible for your skin's smoothness, resiliency, elasticity, and strength.


These proteins are the foundations of your skin. And in mature skin, they are vastly lacking, hence giving it its maturity.


What is considered Mature Skin?

Many think a person's age determines whether or not they have mature skin.


I've even read some reports where anyone over the age of 35 is classified as having mature skin.


Having mature skin has less to do with your biological age and more to do with the condition of your skin.


Things that can play into the age of your skin are things like your genetics, your lifestyle, environmental exposure, your skin type, and any skin conditions you have.


I've seen 35-year-olds with mature skin that looks like cracked leather. And, conversely, I've seen 60-year-olds with skin that looks like they could be 40!


Some of these things you're in control of while others just are what they are.


Characteristics of Mature Skin

The main characteristics of mature skin, at any biological age, are:

  • loss of collagen

  • loss of elastin

  • sagging skin

  • pronounced expression lines

  • wrinkles

  • uneven skin tone

  • sun damage

  • fragile skin

How Peptides Help Mature Skin

Because peptides can penetrate the outer layer of the skin, they're able to work at a deeper level. They send signals to the deeper skin cells triggering them to produce those proteins of collagen, elastin, and keratin.


Types of Peptides in Skincare

There are five different types of skin-repairing peptides: signaling peptides, carrier peptides, enzyme-inhibiting peptides, neurotransmitter-inhibiting peptides, and antimicrobial peptides. (MDPI)


1. What are Signaling Peptides?

These peptides signal cells to help stimulate collagen and elastin production.


As the skin cells turnover, the skin's elasticity increases, pigmentation from photodamaged skin softens, and skin appears smoother and firmer.


The signaling peptides are the ones that work hardest to keep your skin looking young


These are your Matrixyl and Copper Peptides


Signaling Peptides: Carnosine, Copper tripeptide, Trifluoroacetyl-tripeptide-2, Tripeptide-10 citrulline, Acetyl tetrapeptide-5, Acetyl tetrapeptide-9, Acetyl tetrapeptide-11, Tetrapeptide PKEK, Tetrapeptide-21, Hexapeptide, Hexapeptide-11, Palmitoyl pentapeptide-4, Palmitoyl tripeptide-3/5, Palmitoyl tetrapeptide-7, Palmitoyl hexapeptide-12, Palmitoyl oligopeptide, Palmitoyl tripeptide-1, Pentamide-6


2. What are Carrier Peptides?

These peptides stimulate wound repair by carrying trace elements, like copper and magnesium, to specific cells.


These elements have also been shown to increase collagen.


These are your Copper Peptides.


Carrier Peptides: Copper tripeptide, Manganese tripeptide-1


3. What are Enzyme-Inhibiting Peptides?

These peptides inhibit the activity of enzymes that degrade collagen.


They help to slow down the loss of collagen and elasticity in the skin.


Enzyme-Inhibiting Peptides: Soybean peptide, Silk fibroin peptide, Black rice oligopeptides


4. What are Neurotransmitter-Inhibiting Peptides?

Think of these peptides as your peptide alternative to Botox! They inhibit neurotransmitters in the body.


Acetylcholine is the most abundant neurotransmitter in the body and, most importantly, is responsible for controlling muscle contractions.


When muscles contract, wrinkles form.


Using a neurotransmitter-inhibiting peptide inhibits the release of acetylcholine to help reduce wrinkles.


These peptides only work on wrinkles caused by expressions and not wrinkles caused sun exposure.


Neurotransmitter-Inhibiting Peptides: Acetyl hexapeptide-3, Pentapeptide-18, Pentapeptide-3, Tripeptide-3


5. What are Antimicrobial Peptides?

These peptides are produced in the deepest layers of the skin and assist with fighting bacteria, fungi, and viruses.


Once triggered, they travel to the surface to fight off potential pathogens.


They play a vital role in balancing the skin's lipid barrier, supporting immune responses, and wound healing.

Structural Protein Digestion Peptide: Keratin peptide


What are the best Peptide products for Mature Skin?

With so many different types of peptide-infused products on the market from cleansers, toners, lotions, creams, masks, and serums how do you know which peptide product to choose?


What type of peptide delivery system is going to work best to help mature skin?


It's important to choose the right form.


Using a peptide-infused serum, moisturizing lotion or cream is going to be the most effective because they have prolonged contact with your skin.


They allow the peptides to penetrate to the deeper layers where they do their work.


A cleanser containing peptides is much less effective because you put it on and rinse it off.


Using a combo anti-aging skincare product that contains peptides and other complementary ingredients give you more bang for your skincare buck, and help the peptides work better.


Things like antioxidants (Vitamin C, CoQ10, Niacinamide, Matrixyl, Retinol), ceramides, and hyaluronic acid.


As with all ingredients, the higher the ingredient is on the list, the more of it, it contains.


You want to choose a peptide product with the actual peptides listed close to the top of the ingredient list.


Parting thoughts...

There are so many benefits to using topical peptide products. They help to...

  • Reduce the appearance of fine lines

  • Strengthen the skin's lipid barrier 

  • Lock in hydration

  • Aid in collagen, elastin, and keratin production

  • Make the skin firmer

  • Smooth out your complexion

  • Repair damaged skin

I use three anti-aging serums that contain peptides twice a day: CoenzymeQ10, Matrixyl 3000, Matrixyl Synthe'6

And the CeraVe Skin Renewing Night Cream right before bed.


You can read more about the benefits of CoenzymeQ10, here.

You can read more about the benefits of Matrixyl 3000, here.

You can read more about the benefits of Matrixyl Synthe'6, here.

You can read more about the benefits of the CeraVe Skin Renewing Night Cream, here.

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© 2019 Deborah Verga